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Here, we report generation of a genetic model of conditional podocyte ablation and regeneration in zebrafish using a bacterial nitroreductase strategy to convert a prodrug, metronidazole, into a cytotoxic metabolite.
To determine whether Rac1 is required for adult thymus homeostasis we used a model of conditional deletion of Rac1 in post-natal mice.
Briefly, a maximum likelihood phylogenetic tree is constructed for each gene and a model of conditional adaptation is inferred for each observed amino acid at each codon.
The analysis of the total earnings of players also suggests that this heterogeneity can be evolutionarily stable, in the sense that all strategies are (on average) equally profitable, as observed also in [21] (some theoretical support for the evolutionary stability of a simplified model of conditional cooperation in the presence of social norms has been already provided [26]).
We favored this model of conditional gene excision over the routine conditional knock-out strategies because Tcf7l2 is a transcription factor with well-established developmental roles.
The results indicate that the null model of conditional independence ([EA] [EU] between alter's HIV status, A, and unprotected sex, U, given ego's HIV status, E, failed to be rejected.
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Modeling of conditional packet loss probability and busy time sensed by each station is critical for per-flow throughput prediction in arbitrary networks.
We provide a framework for improved modelling of conditional and synergistic interactions from matched transcriptomic and epigenomic data.
Estimates derived from a systematic analysis using Markov modeling of cART survival data for a hypothetical Tanzanian population from 20 observational studies and cohort analyses serve as the basis for our modeling of conditional life expectancies in Uganda [ 19].
Recently, two different mouse models of conditional expression of oncogenic Met variants in the mammary gland demonstrated a causal role for Met in the onset of diverse types of mammary tumors, including BLBCs.
Also recent developments for the BioNetGen language now allow to specify user-defined rate law functions, and moreover, modeling of conditional expressions to support the construction of logical sequences of control [ 30].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com