We have recently shown that ERK5 inhibition enhances the anticancer properties of 5-FU in a murine xenograft model of colon cancer36.
Among her more recent research, Dr. Chen developed a 3D model of colon cancer, grown from human stem cells, that she and her colleague Dr. Todd Evans used to screen drugs that could effectively treat the disease.
Additional evidence of a Th-1 response is demonstrated by tumor growth inhibition in a mouse model of colon cancer metastasis.
To gain more insight into the site- and time- specific mechanisms by which it induces chemoprevention, this study was elaborated over a pre-cancerous model of colon carcinogenesis.
The traditional model of colon carcinogenesis includes several steps that occur via mutational activation of oncogenes and inactivation of tumor suppressor genes.
We therefore investigated whether 4D-ELF would be able to identify preneoplastic changes in the colonocytes of the azoxymethane (AOM -treated rAOM -treatedcolon caratnogenesis.
Our previous work13 provided further evidence that apoA-I and apoA-I mimetic peptides ameliorate cancer in mouse models by immunomodulatory mechanisms in which a model of colon cancer metastatic to the lungs in wild-type BALB/c mice was used.
Using a Tcf4Het/+ ApcMin/+-mediated model of colon tumorigenesis, we found that EE vastly improved the survival of tumor-bearing animals, with differential effect on tumor load in male compared to female animals.
"It's the best model available," Dr. O'Rourke says, "but the tumors don't grow in the same place as they would in people, and they're not cancerous". So he devoted himself to creating a new and better mouse model of colon cancer in the hope of making it available to fellow researchers worldwide.
Such a study on microscopic metastases in the liver has been performed with 177Lu-labeled mAbs in a model of colon cancer [16].
Moreover, antibody-mediated FoxP3 protein therapy resulted in a clinically significant reduction in tumor burden in a syngeneic model of colon cancer metastasis to liver in Balb/c mice [7].
