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Additional regression analyses were conducted simultaneously adjusted for all other IGF1 and IGFBP SNPs to determine the best fit model of circulating levels.
Visual inspection of the residual Q-Q plot from the linear regression model of circulating 25(OH D suggested departure from normality by the residuals.
A mathematical model of circulating IGF-1 (Ac) was developed to include parameters of endogenous synthesis (Ksyn); exogenous uptake (Ka) from the subcutaneous dose (As): and IGF-1 clearance: where dAc/dt=Ksyn − Kout×Ac+Ka×As.
An advantage of our murine model of circulating BM-derived microglia deficiency in retinal degeneration is that, in contrast to most published macrophage-deficiency models, on which BM transplantations were performed after systemic irradiation, in our model, the resident microglia are not ablated after systemic depletion of BM-derived microglia.
These observations, coupled with the fact that isolated RBCs can take up S1P from media, have led to a proposed model of circulating S1P homoeostasis, in which RBCs buffer this lipid and the binding capacity of plasma components, such as HDL and albumin, regulate the release of the lipid from RBCs.
Similar(55)
The modeling of circulating biomarkers (see refs. 59 and 60 for reviews of modeling initiatives) is also a clear avenue in the development of more mechanistic models and for identification of predictive biomarkers.
Mathematical models of circulating fluidized bed (CFB) combustion systems vary from simple lumped models to full-scale 3D models with multi-phase flow fields.
Modeling and simulation of circulating fast fluidized bed reactors (CFFBR) and circulating fast fluidized bed membrane reactors (CFFBMR) for hydrogen production by oxidative reforming of methane are presented in this paper.
In keeping with this mechanism, we observed that in our nutritional and hormonal, eGHI and STZ mouse models, variations of circulating plasma insulin are closely associated with variation of the hypothalamic COUP-TFII mRNA levels, paralleling the modulation of POMC gene expression and therefore of the melanocortin receptor agonist (αMSH) production.
We have described a compact, easily-fabricated microfluidic system to model serial interactions of circulating cancer cells with a vascular endothelium at defined sites stimulated extravascularly from the basal side by chemokines.
In our model the number of circulating tumor cells is linked to the total tumor size.
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Justyna Jupowicz-Kozak
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