He has been collaborating with his Berkeley colleague Tony Keaveny who is already bringing to market a computer model of bone fracture risk from osteoporosis.
The purpose of this study was to develop an in vivo model of bone loss induced by chronic systemic inflammation.
To develop an autologous research model of bone and cartilage tissue engineering, the authors sought to determine whether rat inguinal fat pads contain a similar population of osteochondrogenic precursor cells.
A gelatin hydrogel incorporating bone morphogentic protein (BMP -2 was prepared and implanted suBMP -2eously into mice to obtain an animal model of bone regeneration.
Aln-coated nanoparticles protected bone resorption and decreased the rate of tumor growth as compared to control groups in an intraosseous model of bone metastasis.
On this point of view, we proposed a model of bone remodeling via integrin αVβ3 OPN binding, in which OPN could act as a signal molecule between osteoblasts and osteoclasts in the process of remodeling.
In the present study, we set up an experimental model of bone repair by drilling a 1 mm diameter hole in the cortical bone of femurs in both BSP−/− and +/+ mice.
This approach led to the identification of 4 as a potent, selective αvβ3 receptor antagonist that was selected for clinical development based on an improved PK profile and efficacy demonstrated in an in vivo model of bone turnover.
Here we undertake the initial challenge to develop a mathematical model of bone formation validated with in vitro data obtained from osteoblastic bone cells induced to mineralize and quantified at 26 days of culture.
This study aims to evaluate the skeletal effects of dalbergin (DBN), isolated from Dalbergia sissoo heartwood, in ovariectomized (OVx) BALB/c mice, a postmenopausal osteoporosis model of bone loss.
The technique was applied to study the response of the C57BL/6J@Ico strain of mice submitted to a model of bone loss by hind limb unloading produced by tail-suspension.
