Interestingly, miR-10a expression is lower in Treg of nonobese diabetic mice (NOD), a spontaneous murine model of autoimmune diabetes, whereas miR-10a levels are higher in autoimmunity-resistant C57BL/6 mouse strain [ 22].
Okamoto, M. et al. A transgenic model of autoimmune hemolytic anemia.
Zorina, T. D. et al. Recovery of the endogenous beta cell function in the NOD model of autoimmune diabetes.
Experimental autoimmune encephalomyelitis (EAE) is an animal model of autoimmune demyelination that histologically and clinically mimics multiple sclerosis (MS).
Chow containing 5% but not 0.65% 4-MU was effective at preventing disease in the experimental autoimmune encephalomyelitis (EAE) mouse model of multiple sclerosis as well as in the DORmO mouse model of autoimmune diabetes.
To address this issue, we studied experimental autoimmune uveitis (EAU), a model of autoimmune uveitis, in wild-type (WT) and CD6 knockout (KO) mice.
In this study, we explored the possible immunosuppressive effect of IL-35 ectopically expressed by splenic DCs from nonobese diabetic (NOD) mice, a prototypical model of autoimmune diabetes.
The rationally designed JAK3 inhibitor JANEX-1 exhibited potent immunomodulatory activity and delayed the onset of diabetes in the NOD mouse model of autoimmune type 1 diabetes.
To determine the fertility and abortion rates in a mouse model of autoimmune thyroiditis and its relationship with circulating anti thyroid peroxidase (TPO) antibody.
Here we demonstrate that TH17 cells in a mouse model of autoimmune disease are functionally and metabolically heterogeneous; they contain a subset with stemness-associated features but lower anabolic metabolism, and a reciprocal subset with higher metabolic activity that supports transdifferentiation into TH1-like cells.
This study was designed to evaluate the effect of Radix Astragali on myocardial dysfunction, cardiac remodeling and morphological alteration in an experimental model of autoimmune myocarditis, a clinical condition often resulting in dilated cardiomyopathy.
