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Consequently there is an unease at the thought of the pharmaceutical industry, which has a vested interest in perpetuating a "disease model" of autism for eventual profit, being involved with such research.
Using an animal model of autism, EU-AIMS has already identified a possible drug target on synapses – the connections between nerve cells – where a particular brain receptor was found to be produced in excess.
"We just think it makes more sense to orient research to addressing health problems or helping people communicate rather than creating a mouse model of autism or finding a new gene," Mr. Ne'eman has said.
Therefore, these mice may be useful as an animal model of autism.
To explore that question, Mazmanian and colleagues at Caltech used a mouse model of autism that is thought to approximately recreate three of the disorder's hallmark deficits: lack of social interaction, decreased communication (mice normally emit ultrasonic, birdsonglike chirps), and repetitive behaviors such as compulsive grooming or burying marbles.
By demonstrating that a widely used mouse model of autism does have gastrointestinal problems, and that these problems are associated with behavioral symptoms, the new research "shows us something fabulous," says Betty Diamond, an immunologist at the Feinstein Institute for Medical Research in Manhasset, New York.
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Maternal administration of bumetanide before delivery reduces the autistic phenotype in rodent models of autism.
The team tested its hypothesis in two separate rodent models of autism.
Finally, we will highlight the huge potential impact of newly generated rat knockout models of autism.
Treatment of rodent models of autism spectrum disorder with a drug that alters the function of a neurotransmitter ameliorates autistic-like behavior in offspring.
Over the last years, a huge number of behavioural phenotyping assays for rodent models of autism and related disorders have been designed.
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