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Stefanelli C, Bonavita F, Stanic I, Pignatti C, Flamigni F, Guarnieri C et al. Spermine triggers the activation of caspase-3 in a cell-free model of apoptosis.
A transient intermediate of singly cleaved dimeric caspase-7 can be found in a cell-free model of apoptosis induction.
Another group developed a Boolean logic model of apoptosis signaling in Leukemic T-Cell large granular lymphocytes [31].
Below we have used the method described to analyse a mathematical model of apoptosis.
Thus we claim that the proposed signaling network is an appropriate minimal model of apoptosis signaling.
We adopted the well-characterized EL4 lymphoma model of apoptosis induction [34] with modifications as described [31].
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These findings in the well-characterized mouse model of apoptosis-induced liver injury suggest that serum fortilin levels represent a viable marker of in vivo apoptosis.
To further validate the serum fortilin level as a biomarker of apoptosis in vivo, we turned to a mouse model of apoptosis-induced liver damage in which intraperitoneally administered Armenian hamster anti-Fas-antigen antibody (Jo2) rapidly and selectively induces Fas-mediated hepatocyte apoptosis, leading to severe liver damage without affecting other organs [27].
We illustrate these ideas using new and previously published models of apoptosis.
Par-4 induction is associated with apoptosis in diverse cell culture and in vivo models of apoptosis.
Recently, a 99mTc-labeled Hynic-Annexin V derivative has been described and successfully evaluated in animal models of apoptosis.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com