Sentence examples for model of anthrax from inspiring English sources
We previously developed a 96-h sedated, instrumented, and mechanically ventilated canine model of anthrax toxin-associated shock in which LT and ET were infused over 24 h to simulate release during infection [4].
The National Institutes of Health had agreed to fund the study, which involved creating an animal model of anthrax infection in baboons, and the university's animal use and care committee had given it the green light.
The secretion of TNFα from monocytes stimulated with PGN is consistent with a model of anthrax as a septic disease.
To test the contribution of anthrax toxins to the pathogenesis of CNS infection, we developed a mouse model of anthrax meningitis.
Currently however, no small animal model of anthrax meningitis exists that could facilitate our understanding of disease pathogenesis and the contribution of specific virulence factors to penetration of the CNS.
A continuing problem in vaccine research is devising methods to enhance the immune response and then ensuring that it is protective against disease; for instance, the use of CD40 agonist antibody plus antigen showed remarkably rapid immune response and protection in a murine model of anthrax.
As a consequence of B. anthracis being a widely distributed species, models of anthrax outbreaks are subject to similar limitations in accuracy.
Studies are needed to assess whether intracellular toxin inhibitors, some of which are FDA approved for other indications, are efficacious in animal models of anthrax infection.
Understanding genetic-environmental associations will be essential to accurate modelling of anthrax for use in disease prevention and control in Kazakhstan Presence points for outbreak-based models were taken from the database created by Joyner et.al. [ 26].
The first study that incorporated a mobility model in the simulation of anthrax outbreaks was conducted by Buckeridge [ 4].
These observations reflect autopsy findings in patients [5] validating the utility of this newly developed mouse model of hematogenous anthrax meningitis.
