Sentence examples for model of agonism from inspiring English sources
The operational model of agonism separates the receptor binding and transduction process.
According to the operational model of agonism, τ in vivo serves as the marker of drug efficacy.
To evaluate this hypothesis, the operational model of agonism was fitted to the in vitro data produced from colony forming cell assays for epoetin and darbepoetin.
Figure 3c shows the schematic diagram of various relationships in the operational model of agonism at the predose time point of the first and third IV dose.
Analysis of the concentration response data using the operational model of agonism indicated that both VEGF165 isoforms had similar affinity for VEGFR2.
τ in vivo is known as the efficacy parameter in the operational model of agonism (see "Methods" section) and this parameter is estimated based on the clinical data.
To understand the ligand-selective receptor desensitization, we determined relative efficacy of the β2AR agonists in DMR assays using the Black and Leff model of operational agonism [30].
Analysis of the data using an operational model of drug agonism has allowed us to assess and compare the actual loss of MOPr function that underlies the tolerance that developed to both agonists.
The affinity (KD) of partial agonists was determined from their concentration-response curves using a full agonist concentration-response curve as a reference and the operational model of partial agonism (Leff et al., 1993; Baker et al., 2003a).
Using cimaterol as a full agonist to determine the system maximum response, estimated affinity values of CGP 12177 and BODIPY-TMR-CGP were extracted from their concentration-response curves using the operational model of partial agonism (Leff et al., 1993), and were determined to be 7.58 ± 0.13 (n = 13) and 7.06 ± 0.13 (n = 8) respectively.
The accumulated evidence led us to hypothesise a model for agonism of receptors in the TNF receptor superfamily, which takes into account that these receptors are normally brought into an active trimeric configuration by their naturally trimeric ligands.
