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Why does the MNGIE TP/UP double-knockout mouse model not display the clinical signs typical of human disease?
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vFor the sake of completeness, note that no interaction effect surfaces when multiplicative terms between turnover and firms size are included in the regression models (not displayed in Table 2).
In cases where the developed PBPK model does not display appropriate agreement with adult PK data, subsequent development of pediatric models is cautioned as misconceptions depicted within the adult model are likely to be mirrored in pediatrics.
At crustal depths, anisotropy is almost constant in the models: the fast direction of anisotropy is close to being parallel to the orientation of the RRSZ (NW/SE) in the SW, whereas the NE of the model does not display significant anisotropy.
The DW and LM statistics indicated that the model did not display serial autocorrelation (DW = 1.71, LM = 0.85).
The DW and LM statistics indicate that the model did not display serial autocorrelation (DW = 1.73, LM = 0.24).
The DW and LM statistics indicate that the model did not display serial correlation (DW = 2.05, LM = 0.049).
This model did not display any of the known AD histological alteration and, surprisingly, performed better in cognitive tasks than the age-matched control animals.
Unfortunately, mice, which are favored as lung disease models, do not display a unique RBC resonance, thus limiting the preclinical utility of (129) Xe MR. Here we overcome this limitation using a commercially available strain of transgenic mice that exclusively expresses human hemoglobin.
Unfortunately, mice, which are favored as lung disease models, do not display a unique RBC resonance, thus limiting the preclinical utility of 129Xe MR. Here we overcome this limitation using a commercially available strain of transgenic mice that exclusively expresses human hemoglobin.
The genetic models of PD, established by inducing mutations associated with familial forms of PD, are of limited value because most of the murine genetic models do not display the characteristic loss of DA neurons observed in PD, as they are still at an early stage of this disease.
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