Sentence examples for model neutralization of from inspiring English sources

We have also shown that in our inducible dry eye model neutralization of IFN-γ decreased caspase-3 and caspase-8 and increased conjunctival goblet density [ 24, 29].

In an animal model, neutralization of systemic S1P using Sphingomab, an anti-S1P monoclonal antibody, was shown to suppress lung metastasis [ 70].

In our model, neutralization of IL-17A regulates SDF-1 expression in the metastatic niches either directly or indirectly via reducing levels of IL-6 and M-CSF.

We conclude that in our model, neutralization of IL-17A regulates SDF-1 expression in the metastatic niches either directly or indirectly via reducing levels of IL-6 and M-CSF.

In this model, neutralization of MIF with an anti-MIF polyclonal antibody suppressed the disease activity of colitis, suppressing the production of Th1-type cytokines and MMP-13 in the colon.

In murine arthritis models, neutralization of IL-6 transsignalling by administration of sgp130 was shown to reduce inflammation [ 2, 10- 12].

Unfortunately, despite successful treatment in animal models, antibody neutralization of individual components of this inflammation has not proved beneficial for the majority of patients in clinical sepsis trials [ 3].

In this mouse model, antibody-mediated neutralization of CXCL12 led to reduced fibrocyte recruitment to the lung and decreased collagen deposition [ 5].

We have previously demonstrated a proapoptotic role of IFN-γ in our inducible dry eye model, as antibody neutralization of IFN-γ prevented desiccation-induced goblet cell loss [ 24].

Although the activation of BAK may occur either directly or indirectly, a key feature of both models is the neutralization of antiapoptotic BCL-2 proteins by BH3-only proteins.

These data imply that significant changes in Env spike structure are dependent upon precursor gp160 cleavage and are consistent with a restricted-binding-to-Env model of neutralization.