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The abolished activation of NF-κB in the model might further promote apoptosis, although p53-dependent apoptosis was blocked as well.
Nonetheless, the established practice of interpreting AZFc rearrangements under the auspices of homology-based recombination (usually the most parsimonious model) might further accentuate this bias.
Despite the satisfactory performance of scaling function predictor several tests indicated that implementing a general linear model might further enhance the predictive power of the model.
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Including post-translational regulation in future models might further improve the model's performance at the light-dark transitions.
As diseases linked to aging can involve activation of p53-dependent changes in cellular protective pathways, the development of specific physiological models might further shed light on the role of p53 kinases in modifying age-related diseases.
Based on the experience gained with this prototype, the model might need further improvements before running in production.
This mouse model might facilitate further investigations needed to understand the mechanisms responsible for the breakthrough bleeding frequently observed in progestin users.
In addition, this model might be further improved by other laboratory data (such as haemoglobin and platelet counts) and pathologic characteristics (Huang et al, 2011).
Therefore the model might allow further studies clarifying these crucial steps of angiogenesis and tumor invasion and metastasis which are promising targets for new drugs against solid tumors [ 52, 53].
E.g. sucrose could partly contribute to accelerated inflammation through fructose, which has been shown to activate inflammatory pathways such as NF-κB signaling and to induce oxidative stress in animal models which might further contribute to inflammatory alterations [ 52- 54].
This cognate host calf model might also provide further understanding about HRSV in infants [ 54- 56], with particular usefulness in the study of RSV pathogenesis and pathological processes in the lower airways, where data from infants is limited [ 57], but also to evaluate candidate vaccines that utilize proteins conserved across BRSV and HRSV [ 24].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com