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The detailed biosynthetic pathways have been established for several model microorganisms such as Escherichia coli [ 5, 6] and Saccharomyces cerevisiae [ 7, 8].
Furthermore, numerous successes have been demonstrated for using these models to guide rational engineering in model microorganisms such as E. coli and S. cerevisiae [ 20- 22].
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As an important catabolite activator protein, it has been well characterized in model microorganism such as Escherichia coli.
Addressing DNA lesion, the SOS response is conserved in bacterial domain and governed by DNA binding protein LexA, which have been well characterized in model microorganism such as Escherichia coli.
The accumulated knowledge about such "model" microorganisms, in the most different subjects of studies, and familiarization with their requirements and performance, facilitates the task of genetic improvement and eases the industrial utilization of new strains.
Robust engineering of photosynthetic microorganisms is lagging behind model microorganisms that rely on energetic carbon, such as Escherichia coli, due in part to slower growth rates and increased metabolic complexity.
To our knowledge, the present study is the first one in which the C. elegans model was used to assess the virulence of associated microorganisms such as E. coli and E. faecalis.
Finally, the model presented can also be applied to (i) other types of microorganisms such as unicellular green algae or photosynthetic bacteria, (ii) different photobioreactor processes such as food product or pharmaceutical production, or (iii) photochemical reactors.
Microorganisms such as yeast serve as powerful eukaryotic models for experimentally investigating the effects of microgravity.
Several approaches have been used in the past for imaging of anaerobic microorganisms such as P. gingivalis in ex-vivo or in-vitro host models [21], [37], [38], [39].
Microorganisms such as E-coli, S. aureus and C. albicans form part of the human microbiota.
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