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In this study, we found that ICS model mice show morphine resistance, as often observed in FM patients.
R6/2 HD model mice show an early and progressive metabolic impairment, which is significantly associated with lower glucose uptake, and is independent of cell loss (12).
Thus, the HMSN1A model mice show a strong phenotype which seems to involve muscle fibre atrophy after demyelination of its innervating motorneuron followed by satellite cell recruitment in the regrowth phase after myelination is restored.
Similarly to Spry2 null mice, the Muenke model mice show excess pillar cell development at the expense of Deiters' cell development along the entire length of the cochlear duct, with the most extreme abnormalities occurring apically, and excess outer hair cell development that is confined to the apical region.
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In addition, the HD model mice showed activation of the IRE1 pathway only, indicating it was different from canonical UPR activation to start with.
Although our model mice showed elevated white blood cell counts, splenomegaly, high mortality and bone marrow fibrosis, as previously reported, elevated peripheral RBC and PLT counts were not observed (Supplementary Table 1).
In the N171-82Q malel, mice mice show poorer performance on the rotarod than female mice [37].
We show here that in an immune-mediated nephritis model, female mice show increased apoptosis compared to male mice.
Alzheimer's disease model, Tg2576 mice show abnormalities in hippocampal morphology and physiology and displayed spatial memory but not object recognition [ 26].
In general, the results obtained using PDX models in mice show better preclinical and clinical concordance than those from cell lines [ 11, 14].
In the animal model, ABCA4-knockout mice show deposition of lipofuscin-like substance in the RPE.
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