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To investigate whether hCNS-SCns can contribute to long-term locomotor recovery in an early chronic SCI model mice received grafts of hCNS-SCns, hFbs, or a vehicle control injection 30 days post contusion injury.
For the endotoxemia model, mice received i.p. injections of LPS (22 mg/kg weight) from E. coli serotype 0111 B4 (Sigma-Aldrich, St . Louis MO, USA).
In the premenopausal model, mice received one 60-day release pellet containing 0.72 mg 17β-estradiol (Innovative Research of America, Sarasota, FL, USA) 1 week before implantation of cells.
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In an orthotopic ovarian cancer xenograft model, mice receiving the nanoparticles with both paclitaxel and 90Y at a dose of 500 µg nanoparticles/mouse (20 µg paclitaxel and 1.85 MBq 90Y per mouse) showed significant survival advantage over those receiving monotherapies.
Groups were as follows (n = 9): mice receiving sham operation and Tween-80 (control); mice receiving BDL and Tween-80 (model); mice receiving BDL and treated with NPLC0393 NPLC03933).
Similar to the AOM/DSS model, mice receiving the colon carcinogens (PhIP and DMH) followed by DSS treatment have a higher incidence of tumors [124], [127].
In a more chronic exposure model, mice receiving alcohol for 19 weeks showed both a significant decrease in total PP cells, as well as a significant reduction of T and B cells present in PPs (Lopez et al. 1997).
To generate a type I diabetic model, female mice received a single injection of streptozotocin (Sigma, St . Louis MO) at a dose of 190 mg/kg (dissolved in sodium citrate buffer, pH 4.4).
To determine treatment efficacy in the subcutaneous xenograft model, the mice received a series of treatments, starting 14 days after initial tumor implantation.
In a preclinical model of TBI, mice received vehicle, simvastatin, and rosuvastatin at doses of 1 mg/kg and 5 mg/kg for 5 days after the impact.
To test the restorative effect of CsA in this new model, DAT-CreERT2 mice received an intra-nigral injection of AAV-FlexOFF-α-synuclein vector.
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