In the CIA model, DBA/1 mice given a single intradermal injection of type II collagen in CFA develop a non-synchronous arthritis beginning at around day 20 with highly variable severity.
In this model, mice are given a single dose of alcohol to produce a blood alcohol level of 90 100 mg/dL 4 hours after alcohol administration, at which time they are given a full thickness ~12.5% total body surface area dorsal scald burn.
In a separate model, mice were given injections of cerulein for 10 weeks to induce chronic pancreatitis.
For the subcutaneous model, mice were given 2 injections, one day apart of anti-NK1.1 (PK136 mouse IgG2, hybridoma HB191; ATCC) (200 μg/dose) antibody intraperitoneally.
Our experiments show that the administration of a rat anti-murine RAGE increased survival in the CLP model of sepsis compared with mice given control serum, even with delayed administration as long as 24 hours after CLP.
In CLP and endotoxemia models, survival benefits were evident in mice given 0.1 mg/kg of Bev relative to the CLP or LPS alone (P <0.001 and P = 0.028, respectively), and in 6 h post-treated mice relative to the CLP alone for the effect of different time of Bev (P = 0.033).
In the in vivo orthotropic mouse model using the human MPM cell line, the mice given BIW-8962 had a tendency to develop a smaller amount of pleural effusion.
Diabetic mice given the activator responded dramatically.
Only models that included interactions between three mice gave a good approximation of the observed behavior.
As Clif Barry, the chief of the Tuberculosis Research Section at the National Institute of Allergy and Infectious Disease, once told Slate, "The truth is that for some questions, mice give you a very nice and easy model system for understanding what's happening in humans, but mice are mice, and people are people.
