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Effect of Bifidobacterium breve strain A1 treatment on cognitive function in AD model mice evaluated by Y maze test and passive avoidance test.
Muenke model mice evaluated in four genetic backgrounds have dominant hearing loss that is more severe than that in Muenke syndrome patients, but have the same pattern of relative high-frequency sparing, with variation between strains with respect to the extent of sparing.
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Although few investigators have directly reported the extent of interstitial fibrosis in this model, db/db mice evaluated at 14 – 18 weeks post UNX exhibited a modest increase in interstitial inflammation, interstitial volume, and number of tubules showing dilation or atrophy [ 8, 32, 33].
Third and last, the study by Moreno and colleagues also found that memory loss in prion disease model mice as evaluated by performance in the object recognition task was not restored if the PERK inhibitor treatment was started at a relatively late stage, after the onset of neuronal loss and the appearance of clinical symptoms of the disease.
The global similarity between expression patterns in human psoriasis and mouse phenotypes was statistically significant for each mouse model evaluated.
Nevertheless, at a global level, there is strong and statistically significant similarity between expression patterns in clinical psoriasis and those of each mouse model evaluated by our study.
For example, in a mouse model evaluating the effects of in utero ethanol exposure from days 9 to 11 of gestation, this acute ethanol administration resulted in lower-than-normal methylation throughout the genome (i.e., in global hypomethylation) of fetal DNA (Garro 1991).
Recent mouse model work evaluated these different types of antigen-BCR interactions in the Eμ-TCL1 transgenic mouse model of CLL.
Using the mouse model, we evaluated whether PADRE could improve adjuvant-assisted immunizations with a recombinant malarial protein containing the 19 kDa C-terminal region of merozoite surface protein 1 (MSP119) that is a Plasmodium vivax vaccine candidate.
In a mouse model, we evaluated the effectiveness of intradermal injection of plasmid DNA followed by noninvasive in vivo electroporation (EP) as a method to improve transfection in skin.
Following our results obtained with MR16-1 in the bleomycin mouse model, we evaluated the antifibrotic effects of IL-6 inhibition with an innovative anti-cytokine strategy.
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