Results Here, the authors generated a zebrafish model lacking functional Pten to analyze the role of the protein in cancer and development.
To test this hypothesis, we isolated CD4+ T cells (>90% purity) from 6-month-old B6 and B6.SLE mice and adoptively transferred them to LDLr−/−, Rag−/− mice, an atherosclerotic mouse model lacking functional B and T cells.
To characterize the influence of PRKG1 on sleep and circadian rhythmicity in mammals, we analyzed two different mouse models lacking functional PRKG1 in the brain.
In vivo mouse models lacking functional core 2 and 3 enzymes displayed increased susceptibility to colitis in the dextran sulfate sodium colitis model,, while mice lacking core 1 enzymes developed spontaneous colitis.
In line with these findings, a properly functioning adaptive immune system has previously been shown to be involved in maintaining cognitive health and hippocampal memory formation in several immunocomprised mouse models lacking functional T cells [ 48– 50].
These findings are consistent with earlier studies showing reduced inflammation in mouse models lacking functional MyD88 (Björkbacka et al., 2004; Everard et al., 2014; Michelsen et al., 2004) or TRIF (Richards et al., 2013).
The male Mecp2-null model completely lacks functional Mecp2 expression, and displays a more severe gross behavioral phenotype.
Moreover, the impact of mTOR inhibition on radiosensitization was independent of p53 status as, in contrast to LNCaP cells, the LAPC4 model system lacks functional p53 (van Bokhoven et al. 2003).
The ob/ob mouse, which lacks functional leptin, was chosen as an insulin resistant animal model, and C57/bl6 was used as its genotype control.
