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As expected, the "conventional" model, lacking genetic factors, was not significantly associated with nephropathy in the replication population.
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Another family lacking genetic characterization was the Tupi.
As for most other non-model plant species, we lack genetic and genomic resources for molecular biological study.
Like most other non-model plant species, it has lacked genetic and genomic resources necessary for mechanistic study.
Since these chemical treatments lack genetic specificity, direct manipulation of mitochondrial DNA could have potential to generate genetic cell or animal models mimicking mitochondrial dysfunction.
For example, a high-fat diet model lacks obvious steatohepatitis and genetic models (e.g. leptin, agouti, SREBP1c) often show decreased body weight, cellular fibrosis and inflammation [ 20].
Although technologically advanced, the Mariposans lack genetic diversity.
However, previous data in the literature were obtained using genetic models lacking expression of Dnmt3L, and little is known about which of the domains present in Dnmt3L is required for regulation of epigenetic reprogramming during gametogenesis.
Although instructive, these models lack the gene dosage, mutation variability and genetic background that characterize patients with the disease and that presumably underlie the variable clinical outcome.
Animal and cell models have identified functions of spastin and mutated spastin but these models lack the gene dosage, mutation variability and genetic background that characterize patients with the disease.
Unfortunately, the best-fitted parameters of such descriptive models lack any explicit biological interpretability, in terms of standard population-genetic models of reproduction.
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