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We performed model iterations with several different age categories of housing and presented the best-performing model.
To explore the robustness of the model and to estimate a feasible variation range of the cost-effectiveness results we conducted probabilistic sensitivity analyses and ran a hundred thousand model iterations with random sampling from the distributions.
We also based our results on only 100 model iterations, with further iterations expected to lead to the realization of some other sequences of rare events that we did not yet observe in the model.
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We have already provided some of the analysis requested by the reviewer, in particular running a model iteration with the most recent outbreak excluded.
For each run, we used 50 000 simulation iterations with a null model with 10 groups, each containing 100 demes.
We performed a single modelling iteration with a simple model to demonstrate and evaluate our new modelling approach.
The model was derived using a backward elimination stepwise method whereby at each model iteration, variables with a statistical significance of >0.2 were removed, and the model re-run containing the remaining variables.
All model iterations were implemented in R 3.0.2 with the mnormt, plotrix, and hierfstat packages (Goudet 2005; Lemon 2006; Genz and Azzalini 2013; R core team 2014).
Compared with hydrophilic catheters, gel reservoir catheters are cost effective in 84.6% of model iterations.
Our original model has undergone several iterations, with the aim of better reflecting the biological processes that impact on prion propagation and transmission.
The model converged in 39 iterations, with a chi-square value of 1043.10 with 864 degrees of freedom (p < 0.01).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com