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Following biological validation of a candidate gene in a mouse model, it remains critical to determine its respective role in human disease.
Due to the lack of a routine tissue culture model it remains highly difficult to analyse human bocavirus replication.
Given the mostly unknown parameters involved in our model, it remains to be tested whether the exact predictions agree with actual degradation of multisite proteins such as Sic1.
Nevertheless, although these results are reproducible by the independent coding model, it remains possible that coordinated assemblies underly the observed theta sequences.
However, although generally consistent with this model, it remains to be shown that hyperproliferation signaling mediated by mutant FGFRs leads to DNA strand breaks.
While our data provides genetic evidence that reducing endogenous HDAC6 levels protects against memory impairment in an AD mouse model, it remains to be tested whether pharmacological inhibition of HDAC6 would have similar effects.
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While nacre has demonstrated its effectiveness in multiple cell culture and animal models, it remains a relatively underexplored biomaterial.
With evidence coming from satellites, airplanes, and models, it remains difficult to say with certainty whether the melting at Thwaites represents a true tipping point for the planet or how fast it might happen.
Since our results showed that aureusimines do not play a role in sae-mediated virulence factor production or virulence in animal models, it remains to be determined what roles these dipeptides play in S. aureus.
Although E. nuttalli parasites are as virulent as E. histolytica parasites in animal models, it remains unclear whether they are as virulent in humans (4 ).
In spite of the existence and use of several risk prediction models, it remains a great challenge to determine which specific woman is at high risk for cardiovascular disease, especially in young women.
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CEO of Professional Science Editing for Scientists @ prosciediting.com