MK2-deficient hearts subjected to 30 min ischemia followed by 2 hours of reperfusion in the Langendorff model were resistant to myocardial IRI and also showed a diminished number of apoptotic cardiomyocytes [ 56].
Although a number of mouse strains develop obesity and obesity-associated insulin resistance under certain conditions [ 25, 26] most of these models are resistant to atherosclerosis [ 27].
None of the models are resistant to whitewashing attacks.
Traditional models are resistant to open innovation.
Thus, our proposed models are resistant to model over-fitting and weak signal to noise ratio during the learning phase and can avoid the vanishing gradient problem in this scenario.
This included the colon HCT-15, a multiple-drug-resistant model, which is resistant to taxanes.
Thus, our first objective was to establish a subcutaneous NB xenograft model that is resistant to CPT-11.
This finding is consistent with the melanoma model that is resistant to RAF inhibitor 22, suggesting MEK as a common culprit in maintaining melanoma survival in drug-existing microenvironment.
To further assess whether diet by itself can affect gut microbiota composition independent of obesity, Hildebrandt et al. (12) employed the resistin-like molecule-β (RELM-β) KO mice, a model that is resistant to high-fat induced obesity.
