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First, the model is relaxed about 50 ps relaxation process using a canonical ensemble (NVT) MD simulation in order that the system lies in local potential minimum.
The uniform, constant velocity profile assumption of the classical Burke-Schumann diffusion flame model is relaxed to permit more realistic duct entrance velocity profiles to be accounted for.
(22) From this remark, we observe that the degree of ill-posedness in the biparabolic model is relaxed compared to the classical parabolic case.
If the EM algorithm does not converge for n.comp = 2 or 3 in (a), then the model is relaxed by assuming the variance of each component as equal (this is tailored for a CNV having gains only).
The following tuning steps are applied: If the EM algorithm does not converge for n.comp = 2 or 3 in (a), then the model is relaxed by assuming the variance of each component as equal (this is tailored for a CNV having gains only).
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The results are validated with numerical finite element simulations in which some simplified hypotheses assumed in the analytical model, are relaxed to explore the range of validity of the elastic solution presented.
So, constraints on the previous model are relaxed and processes can be assumed to be inhomogeneous Poisson processes.
Then the differentiation rules in the model were relaxed and the intact virtual epidermis was simulated for 100 iterations under high cell proliferation (stem cell 10%, TA cell 20%) and default cell proliferation (stem cell 1%, TA cell 2%) conditions.
However, this was not obvious under default cell proliferation conditions even when the differentiation rules in the model were relaxed and the intact virtual epidermis was also simulated for 100 iterations (Table 1), suggesting psoriasis might be related to both cell proliferation and differentiation.
This qualitative conclusion is unlikely to be changed when the assumptions of this paper's model are relaxed.
The so-called "Markov assumption" or "memoryless" aspect of the traditional Markov model was relaxed by creating "tunnel states".
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com