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Attribution of geotechnical and geochemical properties to the 3D model is problematic without intrusive investigations and sampling.
From the mechanistic perspective, each of these features of the Nagel model is problematic.
They also say the company's basic business model is problematic, since it relies on men and women being incarcerated in large numbers.
Li Zhuang, a lawyer who was imprisoned as part of the "Striking Black" policy, said that "the Chongqing model is problematic because the city's leaders do not follow the rule of law".
However, the model is problematic for the sizeable subsets of several cancers which show increases in SULF expression.
A variance inflation factor greater than 10 indicates that the model is problematic [ 26].
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He has a tendency to dither and he took too long to recognize that Citigroup's financial supermarket model was problematic.
The failure of a Figure 2 model might result from incorrect placement of null causal connections between some latent effects (so rearrangement of the latent effects could render the model proper) but the failure of the more restricted model might instead be reporting that some latent variables in the Figure 1 model were problematic, even if initially undetectably so.
Nevertheless, using these theoretical models is problematic because of computational complexity and the comparative lack of flexibility.
The use of importance sampling in such graphical models is problematic because it generates many useless zero weight samples which are rejected yielding an inefficient sampling process.
Moving forward and testing the hypothesis of haploinsufficiency as a disease mechanism is difficult, and using mouse models is problematic.
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