Qualitatively, similar behavior was observed when the conductances of other ionic currents (DRK, Ca) were varied: i.e., gradual change of the period and amplitude of tonic oscillations or sequences of bifurcations of various tonic and bursting regimes when the model was poised, respectively, in the tonic oscillation or bursting region on the b-gK1 parameter plane.
When the parameters of the model are poised in the center of the bursting region (b = 0.01, gK1 = 32 nS), variations of gh and gL result in a sequence of spike-adding bifurcations of bursting regimes (red dots in Figure 6a,b) similar to that shown in Figure 4c.
The 2′ and 3′ hydroxyls of the NAD+ ribose in our model were poised to 195D (203D in human SDH), potentially forming hydrogen bonds (Additional file 10: Asp195-NAD.png).
Integrated whole-cell modeling is poised to make a dramatic impact on molecular and systems biology, bioengineering, and medicine — once certain obstacles are overcome.
The results generated by our preliminary model of in vivo lignin biosynthesis are encouraging and demonstrate that mathematical modeling is poised to become an effective and predictive complement to traditional biotechnological and transgenic approaches, not just in microorganisms but also in plants.
These are exciting times, as the marriage between IT and physical innovations and new business models are poised to disrupt some of the biggest and most outdated industries in the world.
That said, from a commercial standpoint, the Model 3 is poised for massive success, regardless: more than three hundred and twenty-five thousand consumers have now placed deposits, amounting to fourteen billion dollars in potential sales.
Currently, Yahoo! and Microsoft are distant Nos. 2 and 3. A Microsoft-Yahoo! union could also makes sense for the future of social networking, a sector that's still in the process of establishing a business model but is poised to be the next generation in communications, and ultimately, the advertising industry as a whole.
The recent report of a nonhuman primate model for CRS is poised to help advance the management of this syndrome.
The Long Branch project, six years in the making and hailed as a model of good planning, is poised to take advantage of the economic times.
