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Here, we highlight important new directions and latest developments, including successful discovery of several genetic susceptibility loci, formulation of the multihit pathogenesis model, introduction of the Oxford pathology scoring system, and formalization of the Kidney Disease Improving Global Outcomes (KDIGO) consensus treatment guidelines.

In this murine model, introduction of a biallelic deletion of FHL2 into mutant ApcΔ14/+ mice substantially reduces the number of intestinal adenomas but not tumor growth, suggesting a role of FHL2 in the initial steps of tumorigenesis.

In another study using an in vivo severe combined immunodeficiency mouse model, introduction of magainins and their analogues to melanoma cells leads to a complete tumor regression [ 22].

In a stochastic model, introduction of 1 infected person has a finite probability of resulting in the rapid extinction of an infectious disease.

To allow construction of the perfect fit model, introduction of items into the regression model employed transformed values according to the respective formulae (SJC and TJC as square roots, and ESR and CRP as their natural logs).

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Building on the previous efforts in the field of immunological kinetic modeling, introduction of new dynamic variables for the first time made possible prediction of the relative stability and localization of the immunological synapse, which are important in immunological cell interactions.

Honda's most important model introduction -- a 2002 version of its CR-V, a small sport utility vehicle -- was always scheduled for mid-November, Mr. Garner said.

Nevertheless, the example of YFHS model introduction in Tajikistan is exemplary.

For consistency, we similarly model the introduction of antigenic mutations at transmission in the phylodynamic model.

Because these models are approximate models, the introduction of process model mismatch may have a significant effect on the success of the process optimization.

With the need for more accurate and sophisticated models, the introduction of computational models like the discrete element method (DEM) has started to solve some of the complex problems in comminution.

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