For example, a network could be constructed specifically to model interactions occurring in mitochondria, which is also a category under-represented in BIOGRID (Table 1).
The skip feature model interactions occurring much later in the pathway, for example, a gene g i inhibits a gene g j to start a process, and later g i regulates another gene g k towards the end of the process.
Time discretization is clearly an abstraction of the real system being modeled, where interactions occur in continuous time and over differing time scales.
Some key differences from that haystack model are (i) interactions occur between two species; (ii) each patch is constituted with a single individual or genotype of each species; (iii) we will specifically vary the time at which mixing occurs among patches, rather than allow the patch dynamics to reach an equilibrium.
We restricted our model to interactions occurring at the membrane level, calibrating downstream events using the experimental dose response curve for the WT-IFN monomer (see Methods section).
The linear feature attempts to model interactions which occur instantly or with little delay.
This model implies that two kinds of interactions occur between envelope proteins and CD81LEL: one is strong, the other is weak.
As a model, consider a population where social interactions occur within groups, each consisting of n individuals (note that above, in the population genetic formulation, we assumed groups were large, unlike here where group size is explicit; see also Wade 1980).
This makes them ideal for answering questions related directly to how and why social associations or interactions occur, from the modelling of population level transmission, through within-group behavioural dynamics to social evolutionary processes.
Indeed, the statistical model applied by the researchers assumes that no interactions occur between our DNA blueprint and external toxins like tobacco.
