The models integrate age, cancer cell type and either 5 or 19 markers including, CD34MVD, p21ras, p21WAF, BCL2, caspase-9, low-molecular-weight cytokeratin, high-molecular-weight cytokeratin, cyclooxygenase-2, EMA, HER2, matrix metalloproteinases (MMP -2, MMP -2 p16, p27kip1, p53, vascular endothelial growth factor, β- catenin, and tissue inhibitors of metalloproteinases (TIMMP-9 and TIMp27kip1
The model integrates both current and previously published data relating to molecular biology, physiology, ageing and nutrition in an integrated fashion.
Dr. Stoyan's model integrates the increased number of travelers.
The model integrates variable speed pumps for modeling the pumps operation, two water quality objectives (one based on chlorine disinfectant concentrations and one on water age), and tanks sizing cost which are assumed to vary with location and diameter.
A finite element (FE) model integrating unified asymmetric creep-ageing constitutive model for CAF of AA2050 has been developed through a commercial FE software-PAM-STAMP and a simplified machining-induced residual stress field for aluminium alloy plates has been proposed and implemented into the FE model.
A spatially structured age-and stage-based hierarchical Bayesian model integrating various aspects of ecological knowledge, data sources and expert knowledge was built to quantitatively describe this complex life cycle.
What's needed is a transition to a new model, integrating social, environmental and economic factors.
A model integrating these different levels of information is proposed.
These cancer type-specific or endpoint-specific models integrate clinical (for example, diabetes, age, smoking, hormonal therapy) and dosimetric (mean doses to critical normal tissues) to obtain an estimate of the probability of developing toxicity.
Additionally, the models were age integrated and therefore the models for U5 mortality were informed only by data using the same age ranges in the observational studies.
