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Because subject-specific information was unavailable for certain model inputs, we used the same assumptions for all individuals.
By giving flexibility to change model inputs, we provide users the ability to conduct any sensitivity analysis desired.
Furthermore, to formally evaluate the impact of uncertainty surrounding the point estimates for the model inputs, we conducted several sensitivity analyses to test the robustness of our conclusions.
To sample the space of active model inputs, we construct a space filling Latin hypercube with a maximin design (Morris and Mitchell 1995).
In order to assess the impact of statistical uncertainty around key model inputs, we performed a series of univariate and probabilistic sensitivity analyses.
Because of uncertainty surrounding the point estimates for various model inputs, we conducted several Monte Carlo simulations and sensitivity analyses to assess the stability of these observations (Table 5).
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To evaluate the extent to which performance measures are affected by initial model input, we tested the sensitivity of bite force, strain energy, and stress to changes in seven parameters that are required in testing craniodental function with FEA.
By using the corresponding ChIP data as the model input, we reached a PCC of 0.71 (Additional file 1, Figure S10) which is slightly lower than that of the originating cell line.
To develop an exposure regime for the IEUBK model input, we note that indoor residential dusts generally show Pb concentrations about two times higher, on average, than the corresponding outdoor soils, although these results may have been influenced by fine particulate automotive Pb emissions (Clark et al. 1988; Rabinowitz et al. 1985; Thornton et al. 1990).
To determine the model input Ainf, we used a literature-reported leakage area model and parameter values (14).
We assumed that fish consumption in the population of older men from Northern Norway was higher than the original model input; therefore, we derived separate predictions based on average Norwegian fish consumption and three categories of higher fish consumption (for detailed information, see Supplemental Material, pp. 3 4 and Table S2).
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