Collagen-induced arthritis (CIA), a murine experimental disease model induced by immunization with type II collagen (CII), is used to evaluate novel therapeutic strategies for rheumatoid arthritis.
One was inflammation-related fibrosis mouse model induced by lipopolysaccharide (LPS), and another was bleomycin (BLM -induced rat pulmonary fiBLM -induced
This suggested that large dose ISO induced heart failure rat model could also be used as heart failure model induced by AMI [ 27].
A number of reports have suggested that the ageing model induced by d-galactose is associated with oxidative stress33.
Xin W, Li X, Lu X, Niu K, Cai J. Involvement of endoplasmic reticulum stress-associated apoptosis in a heart failure model induced by chronic myocardial ischemia.
To test this mechanistic hypothesis in the hepatitis model induced by a viral pattern, we administered ETA, a decoy receptor of TNF-α, 1 h prior poly I C injection.
Indeed, in another mesothelioma model induced by asbestos in Nf2+/−; Cdkn2a+/− mice in a FVB genetic background, blockage of IL-1β using IL1β receptor antagonist anakinra delayed mesothelioma development, indicating a promoting role of IL1β.
For further validation, the chronic liver injury mice model induced by carbon tetrachloride (CCl4) was established as described previously19, generating LSEC dedifferentiation at 6th week after CCl4 administration (Fig. 3B).
The arterial thrombosis model induced by ferric chloride (FeCl3) oxidation and the venous thrombosis model induced by inferior vena cava ligation were established to evaluate the antithrombotic potential of XECG.
Further studies demonstrated the protective effect of 4k in mouse Acute Lung Injury (ALI) model induced by lipopolysaccharide (LPS).
Antitussive activity was investigated on a classical mouse cough model induced by ammonia liquor.
