The lectures explain the I-AIM model (indication, acquisition, interpretation, and medical decision-making) to students as a guide for utilizing focused ultrasonography [33].
For the femoral condyle – which was the primary location recommended – ASTM suggested that defect size should not exceed 15%to20%0% of the articulating surface, or 50% to 60% of the condylar width, with depth varying from 1 mm to 10 mm depending on intended purpose, animal model, indication, and controls and cohorts used in the study design.
Once corrected for interspecies PK differences, the model provided indication of which dose and regimens should be investigated in a phase I dose escalation trial.
This was in line with a higher AIC of the models containing creatinine-based CKD definitions compared with the AIC of the reference model, an indication of worse model fit.
All clinical variables listed in Table 1, in addition to age and sex, were entered into the logistic models with indication for catheterization also modelled (categorized as: MI, unstable angina, stable angina, or other indications [reference group]).
The increase in efficiency compared to traditional modeling is such that one can leave behind the idea of building a single model with indications of uncertainty levels.
However, given the number of models that are fit, as well as the number of predictors in each model, these indications of significance should be taken simply as guides to potentially interesting results and not be over-interpreted.24.24
(C) Top view of the BV P dimer (surface model) with indications of the two P monomers (grey and sand, respectively), Leb tetrasaccharide (stick model), and the amino acids forming the HBGA binding interface (cyan).
The model gives indications on the processing conditions to be used to produce an acceptable powder from a very dilute carbohydrate aqueous solution together with a maximization of the evaporation capacity of the drying equipment.
It is curious that, despite the striking functional improvements and molecular myogenesis in the mdx and ischemic models, no indication of myogenesis was evident in atrophic animals.
They used several variables in their model including indications for surgery, menstrual history, dysmenorrhea, dyspareunia, pelvic pain, bowel/urinary symptoms, pregnancy/infertility history, personal characteristics and family history [ 36].
