The apparent discrepancy between these studies may stem from the use of different models; indeed, the piglet model appears as more physiological and closer to the human case than the rodent model, which may account for a different spatio-temporal evolution of damage.
However if this model is incorrectly specified then this test has less power than the Bonferroni approach with no assumptions as to the sub-model: indeed the loss from miss-specification exceeds the gain from correct specification.
However, the biochemistry, the cellular phenotypes, the serology and the histopathology are all quite distinct in these models; indeed, the clinical features are also different.
Conversely, one of the strengths of the MMTV-Luc2 mice lies in the increased feasibility of this system over Cre-activated models; indeed, the MMTV-Luc2 model could be found desirable for some transgenic projects, especially ones utilising non-Cre-activated oncogenic strains, such as MMTV-PyVT.
The notion of system at each of the perspectives in the model indeed includes the omission of detail, but what is omitted in each case is not derived from the strata immediately below.
A preliminary study showed that the inclusion of this dependence on the single-diode model indeed increases the model accuracy, reducing the average error on the performed tests by more than half comparing to the original model.
The model indeed provided the structural rationale for its interaction with ligands and the cofactor and revealed unique characteristics of its binding site which could be exploited for improving the specificity of the inhibitors.
This perfect correlation strongly suggests that the hydrogel model indeed has the potential to faithfully describe the permeability barrier of NPCs.
