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In 2004 we opened a second full-scale model incorporating significant improvements identified through experience.
We created a predictive clinical model incorporating significant findings and found an AUC of only 0.47 at 18-month time point, indicating the generally low discriminatory ability of the clinical variables and perhaps explaining the conflicting findings in the literature for the majority of these variables.
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We developed minimally and fully adjusted logistical models incorporating significant confounders and effect modifiers to compute OR and 95% CI using SAS V.9.2 (Cary, North Carolina, USA).
Since it was observed that results improved when the volatility models considered breaks, incorporating significant events in the GARCH models was suggested.
This did not hold in a multivariable model incorporating all significant factors.
In addition, a final parsimonious model incorporating statistically significant covariates to the model based on a 10% change to the HR for TWA arsenic exposure.
In comparison, the epistatic model incorporating only significant SNPs had AUCs of 0.57, 0.59, and 0.24 and the main effects model with all 14 SNPs had AUCs of 0.6, 0.6, and 0.59.
A multivariate Cox regression model incorporating all significant factors (univariate Cox regression p value <0.05; see online supplementary figure S8A) and year of surgery, revealed that CD68 and CD3 were the only immune markers with independent associations with survival, however, their relationship with prognosis is complex and non-linear (see online supplementary figure S8B).
Firstly, unmeasured confounders could have affected the results of this study, although we have accounted for measured confounders by incorporating significant covariates into the final model.
The model incorporates a significant quadratic time-by-response interaction.
Secondly, each hospital was compared with all the others combined by Cox's proportional hazards model, incorporating the identified statistically significant prognostic factors.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com