The logistic regression model incorporated five gene methylation signatures at AGTR1, GALR1, SLC5A8, ZMYND10 and NTSR1, adjusted for age, sex and smoking, showed robust performances in which the sensitivity, specificity, accuracy, and area under the curve (AUC) were 78%, 97 %, 87, and 0.91, respectively.
Using the recent release of the mirBase database to find potential targets of miRNAs, this model incorporated twelve structural, thermodynamic and positional features of miRNA:mRNA binding sites to select target candidates.
17, 20 The conceptual PK model incorporated three main hypotheses: zero‐order absorption with a limited absorption window, fast equilibrium binding to both AAG and albumin (low capacity and high affinity for AAG; high capacity and low affinity for albumin), and slow intrinsic clearance of unbound vismodegib.
Accordingly, the final multivariate logistic regression model incorporated these three variables (table 5).
The model incorporated the three main signalling pathways, i.e. IRE1 α, PERK and ATF6, the interconnections between these pathways, and the downstream genetic regulatory interactions.
The intervention was based on a psychosocial educational model that incorporated four 2-hour sessions focused on communication, stress appraisal, adaptive coping strategies, and building social support.
Founded in 1877 as the first Japanese institution of higher learning formed on a Western model, it incorporated three schools established in the late 18th and 19th centuries devoted, respectively, to the Chinese classics, Western studies, and Western medicine.
EIS experimental data were fitted and analyzed by an equivalent-circuit model that incorporated two time constants: one representing the properties of the carburized layer and one representing those of the passive film.
The multilevel analysis used a two-level binomial logit model that incorporated six individual level (level 1) variables and eight clinic level variables (level 2).
Models that incorporated three time-lagged periods (1 to 4 years) of local moisture conditions confirmed that salamanders and invasive predators responded differently to drought, reflecting how life-history strategies shape responses to disturbances.
The study by Laneri et al 22 used a vector-susceptible-exposed-infected-recovered-susceptible (VSEIRS) model although they incorporated two different pathways from recovery to susceptibility that were based upon different timescales (seasonal and interannual), mimicking different transmission intensities.
