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= 199, P < 0.0001; model including worm microsatellite genotype as factor: LRT, χ2 = 854.55, d.f.

However, they are both significantly worse than the respective saturated models (model including worm strain: LRT, χ2 = 491.32, d.f.

The two respective models employed are significantly better than models without any predictors (model including worm strain as factor: LRT, χ2 = 1285.63, d.f.

For these OLR analyses, the models employed were significantly better than a model without any predictors (model including worm strain as factor: LRT, χ2 = 62.29, d.f.

Moreover, they were not significantly worse than the respective saturated models (model including worm strain: LRT, χ2 = 4.62, d.f. = 7, P = 0.7060; model including worm genotype: LRT, χ2 = 1.32, d.f. = 3, P = 0.7238), suggesting that they contained sufficient details to explain the observed variation.

Similar(55)

NAD+ levels also decline during aging in multiple models including worms, rodents and human tissue [17, 45, 67, 72].

Current data demonstrate that insights into the mechanisms that lead to the development of NEC and IBD can be gained from studying different models, including worms, flies and vertebrates.

In this Commentary, we explore the role of biological models including worms, flies and mammals in elucidating the pathogenesis of intestinal inflammatory diseases.

Studies in animal models including worms, flies, zebrafish and rodents support the notion that alterations in these RNA-binding proteins and in RNA metabolism cause motor neuron disease (Couthouis et al., 2011; Estes et al., 2011; Lanson et al., 2011; Li et al., 2010; Liachko et al., 2010; Lu et al., 2009; Wegorzewska et al., 2009).

To generate gene knockout organisms, gene editing using transcription activator-like effector nucleases (TALENs) technique has been introduced to various model animals including worm, cricket, zebrafish, and rat (Wood et al., 2011; Huang et al., 2011; Tesson et al., 2011; Sander et al., 2011; Watanabe et al., 2012).

Application of advanced genomic approaches in humans and model organisms, including worms, flies, fish and rodents, has generated vast amounts of data, which has been reported in publications and public databases (2 4).

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