Impact of chemotherapy-induced changes (high versus low) on pCR (multivariate model including tumor phenotype).
This difference was significant also in a multivariate model including tumor stage, MSI status, patient age and gender, as well as tumor location (HR = 3.2; 95% CI, 1.5 to 6.7; P = 0.002).
In a multivariate model including tumor stage, MSI status, patient age and gender, as well as tumor location, sTIN was the strongest independent prognostic predictor (HR = 3.5; 95% CI, 1.5 to 8.3; P = 0.004).
In a multivariate model including tumor stage, MSI status, patient age and gender, as well as tumor location, TIN was close to being an independent predictor of poor prognosis (multivariate HR = 3.1; 95% CI 0.9 to 11.2; P = 0.08).
Moreover, this detrimental effect on disease outcome was significant in a multivariate model including tumor stage, gender, tumor ocation and MMR status in the model (HR=4.74 95% CI 1.47-15.34 p=0.009) (Table 4).
Univariable and multivariable Cox proportional hazards model, including tumor grade, receptor status, clinical tumor size, lymph node involvement and NLR were fit to determine the clinicopathological parameters that were significantly statistically associated with DFS and the results were reported, including hazard ratios (HR) and 95%% confidence intervals (CI).
The model includes tumor's own characteristics, the host immune response, and level of tumor vascularization.
Variables in the model included tumor size, histologic grade, and lymph node metastasis.
The agents are being tested in preclinical cancer models, including tumor transplant models and genetically engineered models of spontaneous cancer.
Multiple linear regression models, including tumor volume on day 0 or tumor volume on the day of sacrifice, were used to evaluate the extent to which the time trends were confounded by tumor volume.
EMMPRIN has been implicated in tumor invasion and its elevated levels in cancer tissues have been correlated with tumor progression in numerous malignant tumor models including tumors of the oral cavity and larynx [ 11, 12].
