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Antitumour activity was evident in macrophage ablated mice, suggesting that non-macrophage-dependent mechanisms may contribute to the in vivo activity in this model, including direct apoptotic signalling in tumour cells.
These findings indicate that all mechanisms contributing to anti-lymphoma activities by SGN-40 are dependent on Fc interactions in this NHL model, including direct apoptotic signalling in tumour cells.
2STEP: two-step approach; LAM: linear animal model including direct and associative effects; CBV: classical breeding value; DBV: direct breeding value: SBV: associative breeding value; DSBV: combination of the direct breeding value of the individual itself and the associative breeding value of its group members.
Estimated breeding values (EBV) based on average daily gain from 0 to 45 days (0-45 dADGADG) obtained with an additive animal model (including direct and maternal effects) were used to classify the animals into different maternal and direct genetic effects groups.
Two methods to estimate genetic parameters were compared: 1) LAM, a linear animal model including direct and associative effects applied directly to the observed survival days; this procedure is described in detail in [ 8], and 2) 2STEP, a two-step approach [ 29].
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Each model includes direct and indirect methods.
This new model includes direct out-gassing of CH4 and CO2 from organic carbon biodegradation, dissolution of directly produced CO2, and sorption with H+ exchange to improve pH buffering.
Our model includes direct medical costs only.
The model included direct costs ie, the cost of diagnosis and treatment, visits to the general practitioner, and the annual cost of asthma for those who developed the condition.
The goal was to create comprehensive models including direct relationships between workplace incivility and its outcomes, as well as mediation and moderation of organizational factors.
The business model includes direct-to-consumer sales, the ability to license software to developers who can build apps that take advantage of the technology.
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