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The landcover model included terms for pond size, geographic isolation, and amount of surrounding agriculture.
The model included terms for the outcome (survivors, deaths from MOF and late deaths), the time (continuous) and an interaction term between time and outcome.
The model included terms for treatment as a fixed effect and the baseline measurement as a covariate with the aim to assess the treatment difference.
The adjusted model included terms for IgG or IgM status, age at baseline, gender, education level, APOE-ε4, time (time in years since the baseline visit, i.e. the blood sampling) and interaction terms between time and each covariate.
The model included terms to estimate cohort effects.
The baseline regression model included terms for gender, ethnicity, residual kidney function and pre-dialysis weight.
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Heritability was high for all three traits (h2UTT = 0.41 ± 0.07; h2BW = 0.46 ± 0.04; h2Kf = 0.52 ± 0.04) in an extended animal model including terms for strain origin and hybrid effects.
The data best fit a sigmoid Emax pharmacodynamic model including terms for baseline effect, as baseline percentage HIV inhibition was not 0 (reflecting endogenous activity of genital tract secretions).
1: Zero-inflated negative binomial model, including terms for age, education level and dental attendance.
It was analysed using a generalised linear model, including terms for the treatment allocation and the variables on which the randomisation was minimised.
We performed a likelihood ratio test comparing a full model, including terms for age, storage, PON1 genotype, and the interaction between age and genotype, with a restricted model without the age terms.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com