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The best-fitting model included additive genetic and nonshared environmental components, each accounting for about half of total variance in the symptoms.
Using the lower cut-point, the best fitting model included additive genetics (A) and unique environment (E), with a heritability of 45% as shown in Table 2.
The final model included additive between-subject variability on PLAC.
The final model included additive between-subject variability on placebo effect (PLAC) and exponential between-subject variability on Emax and K.
This model included additive genetic variance and maternal identity (i.e.,'dam') as random effects, plus age, sex, and cohort as fixed effects.
The full model included additive genetic (A) and shared (C) and non-shared (E) environmental factors that were allowed to differ as a function of sex and age (M).
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By combining models (1) and (2), a model including additive and epistatic effects was formulated: 4 with, and.
The standard G-BLUP model including additive effects only is 1 where y i represents the phenotype of the ith line, μ represents the intercept, g i represents the additive genetic value, and e i represents the residual.
With the LC model, the adjusted phenotypes were fitted to a linear model including additive and dominant components [ 27] and the chromosome-wide significance thresholds were determined by permutations of data as described by Churchill and Doerge [ 28].
Using MCQTL, we performed tests among all pairs of marker loci to detect epistatic interactions with a model including additive, dominance, and epistatic effects and all identified QTL [ 28].
Prediction accuracies for the first validation strategy (no field presence of validation set) are shown in Figure 3. Correlation between the observed BLUP-GV and genomic predicted GV (i.e., GEGV) was essentially the same for the additive model (model A) and for the model including additive and nonadditive effects (model ADE), and varied from about 0.15 (for JUI) to 0.35 (for FF).
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