In our multivariate linear regression model including possible confounders, preoperative eGFR, differences between preoperative MAP and mean CPB pressure, and blood lactate level at 2 h after CPB were independently associated with ICU-free survival days (Table 4).
In our multivariate linear regression model including possible confounders, LAC⊿ >2mmol/L was independently associated with increased the duration of ICU stay (p = 0.028) (Table 3).
However, the complexity of the cost model, including possible non-linearity, and the structure and degree of errors in some exposure variables may preclude a fully-optimized cost efficiency model and instead favour a numerical rather than analytical approach.
A general model, including possible influencing covariates, namely mechanism of injury gender, age in years, was applied to the data and by a stepwise approach the statistically non-significant factors were removed from the model.
In the fully adjusted model, including possible confounders, perceived reduced ability to walk far due to the complaints (OR = 2.6; 95% CI = 1.3-5.4), pain during activities (OR = 2.4; 95% CI = 1.1-5.1), and having been to a PT prior to participation in the trial (OR = 2.1; 95% CI = 1.1-4.3 1.1-4.3ted non RTW at 1 year (table 3).
Multivariate models included possible confounders as covariates, based on the known risk factors for non‐communicable diseases: age, sex, BMI, physical activity, smoking status, fruit and vegetable intake, red meat intake, alcohol intake, and salt intake.
Multivariable Cox proportional hazards models were constructed to include possible confounders and effect modifiers when appropriate, and variables were removed from the model one by one to evaluate the change in hazards of the main effect variables.
Disadvantages include possible lack of model fit, increased sample size requirements and the need for more specialised computer software [ 41].
The model proposed (including possible variation) thus implies many predictions that could be experimentally tested.
The model includes both possible enhancement of mass transfer due to the presence of small adsorptive particles as well as reduction of the mass transfer rate due to the presence of particles adhering to the gas liquid interface.
