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Tonon F, Zennaro C, Dapas B, Carraro M, Mariotti M, Grassi G. Rapid and cost-effective xenograft hepatocellular carcinoma model in Zebrafish for drug testing.
To establish an appropriate stress model in zebrafish, we tested various toxins, such as mitochondrial toxins (rotenone, CCCP) and excitotoxins (L-glutamic acid, kainate).
The aim of this study was to establish an inflammatory lymphangiogenesis model in zebrafish.
In summary, we have established a novel inflammatory lymphangiogenesis model in zebrafish larvae.
As a result, we have produced and characterized an mbnl2 knockdown model in zebrafish, which exhibits features of DM.
A role for another myeloid-derived cell type, the neutrophils, in determining the site of metastasis was suggested in a dissemination model in zebrafish.
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These mouse models, coupled with models in zebrafish and spontaneous disease in pet dogs, form the basis for a new pre-clinical testing platform that can rapidly establish efficacy of numerous therapies across a range of species and OS subtypes.
Premature aging could also be modeled in zebrafish embryos.
This has been exploited for establishing melanoma models in zebrafish, which coupled with the ease of administration of chemicals through the water make them ideal for drug screening [4].
Myeloid leukemia has also been modeled in zebrafish.
It is apparent though that some tumor types are better modeled in zebrafish than others.
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