Sentence examples for model in yeast from inspiring English sources

However, at present, our data are not sufficient to propose a similar model in yeast, and this remains a topic for future study.

Gomes et al. [ 32] created a model in yeast that expresses wild type human TTR protein or the highly amyloidogenic L55P TTR protein.

By setting different thresholds, a receiver operating characteristic (ROC) curve for our prediction model in yeast can be obtained and is shown in Figure 1B.

A critical control in establishing the model in yeast was the demonstration that the introduction, by genetic engineering, of PLA2 enzymatic activity into AtnL generated a protein capable of reducing endocytosis in the same way as AtxA.

The enzyme and the entire methionine salvage pathway seem to be functionally conserved in yeast [ 76] and should therefore serve as an adequate model in yeast experimentation to validate predicted loss of function due to the contained nsSNV.

Biological mechanisms for ROP autocatalysis have been proposed, for example via scaffold proteins that might recruit and activate ROP GEFs [4]; auto-activation of Rho GTPase through an effect on GEF activity has been modeled in yeast [22].

The synthesis of antimalarial precursors was optimized with extreme pathways-based modeling in yeast.

An integrated analysis of data available from genetic screens of regulators of neurodegeneration in various disease models in yeast, fly and worms has identified 34 shared regulators.

Schwartz and Kanehisa [ 19] showed that a combination of structural and kinetic modelling in yeast glycolysis significantly constraints the range of possible behaviours of a metabolic system.

When modeled in yeast Bcs1p, several pathogenic mutations in the AAA region of human BCS1 were shown to prevent respiration in yeast owing to a blockade in the assembly of CIII (Ostojic et al., 2013).

In detail, moderate CR (modelled in yeast by reducing the glucose content of the media from 2%to0.5.5%) leads to a 25% increase in the RLS together with increased transcription of respiratory genes and a higher rate of oxygen consumption [ 21].