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The parameters are sorted by the sensitivity scores (based on the original model) in decreasing order; * indicates original model parameters without a counterpart in the hybrid model.
On multivariate analysis, all above factors entered the model (in decreasing order of statistical significance: expected stress, negative anticipation of assignment completion, androgen trait, and back pain during service).
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The next best univariate models in decreasing order of overall fit were the models based on dichotic, trail, rey-copy and paper neuropsychological tests.
Our current findings illustrate that the expression of CaM-peptide in a neuronal HD cell model results in decreased TG-modifications of mutant huntingtin and decreased cytotoxicity.
The introduction of anti- miR-21 to MCF-7 BC cells and in mouse model resulted in decreased cell growth (via increased apoptosis) and in reduced cell proliferation [ 319].
Reducing mitochondrial fission in two fungi models resulted in decreased mitochondrial fragmentation and extended lifespan by increased resistance to induction of apoptosis [16].
Together these results suggest that accumulation of PrPRES at the ER in familial PrD models results in decreased ER calcium content.
Systemic administration of miR-26a with adeno-associated virus in mouse models results in decreased cancer cell proliferation and suppressed tumor progression [ 23].
Immunotherapy targeting amyloid deposition in both mouse models resulted in decreased alternative inflammatory markers and, in the case of passive immunization, a transient increase in pro-inflammatory markers.
Recent studies have demonstrated increased expression and activity of ILGFR-1 in HCC tumors [ 31], and inhibition of these receptors in animal models results in decreased metastatic potential of HCC tumor cell lines [ 32].
The shR-P16 allowed phenotype correction in a cellular SCA7 model system, resulting in decreased levels of both mutant and wild-type ATXN7 aggregates.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com