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In particular, brain organoids can be generated that can be used to model various neurodevelopmental or neurodegenerative disorders that have been difficult or impossible to model in animals.
The present study is the first experimental analysis designed to model in animals the localized cortical C.O. inhibition found as the earliest metabolic sign of early-stage AD in human neuroimaging studies.
It was concluded that impaired memory by local C.O. inhibition in the PCC may serve to model in animals a metabolic lesion similar to that found in patients with amnestic MCI and early-stage AD.
Though not capable of consciousness or other higher cognitive functions, the minibrains allow scientists to study aspects of the developing human brain that are difficult to model in animals.
The plaques represent an obvious endophenotype to model in animals, and this strategy has been widely used by Alzheimer investigators.
On the other hand, we have demonstrated that a dextran derivative (CMDB) was not only antitumoral but also antiangiogenic in a MCF-7ras tumor model in animals.
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Subsequently, the chicken has emerged as a premier model in animal agriculture [ 2- 4] and developmental biology [ 5].
Migraine with aura is a complex neurological disorder modeled in animals by cortical spreading depression.
This delivery system demonstrated remarkable antitumor efficacy in various orthotopic human cancer models in animals.
Current assessment of orthotopic tumor models in animals utilizes survival as the primary therapeutic end point.
Modeling schizophrenia in animals represents a formidable challenge because the most characteristic symptoms of this disorder, auditory hallucinations and delusional beliefs, cannot be directly modeled in animals.
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