Tissue and organ electrophysiological modelling still requires significant computing power that may not be easily available for routine work [although improvements in hardware and model implementation have reduced this overhead very significantly in recent years (Niederer et al., 2011b)].
The model's managers focus on the achievement of the model's objectives, highlighting results in the form of increased coverage of populations who, prior to the model's implementation, had no access to formal health services, as well as the efficient use of resources based on the differences in the productivity/investment ratio between contracted and public units.
The Butterfly model implementation mechanism has a three-layered architecture: Gray, Yellow and Green.
Secondly, the governance model and the technical implementation has been evaluated by the utilising a number of use cases supplied by our construction project management industry partner.
In the ensuing 9 years, the field has expanded considerably and further taxonomies, checklists, conceptual frameworks, theories, and models of implementation have been developed [ 10, 13, 14, 17, 18].
Although PrEP implementation has been modeled before by us [4] and others [31], [32], [33], [34], [35], [36], [37], we report here for the first time the main drivers of drug resistance from PrEP in a heterosexual HIV epidemic using a carefully stratified and well-parameterized mathematical model of HIV transmission.
In quality improvement programs, the importance of role-models (so-called "champions") for successful implementation has long been recognized [ 35].
Model implementation experiments have revealed that GAMEDE is also a useful tool to support discussions and to generate knowledge exchange among various stakeholders who play an important role in the development of farm sustainability: farmers, extension agents and researchers.
In current model implementation we have not explicitly included binding of ER with its transcriptional co-regulators (such as AIB1, SRC1, NCoR and SMART) and only indirectly accounted for activatory/inhibitory action of these molecules via variation of relevant rate constants of transcription.
