The event-based model impedes the patient from deciding freely and deliberately, as the patient remains unaware of possible biological consequences of radiological interventions.
Therefore, simple explicit integration methods are unsuitable because of a small step size, while on the other hand, the nonlinearity of the model impedes the use of implicit integration methods.
There is increasing awareness in the planning community that depending on complete models impedes the applicability of planning technology in many real world domains where the burden of specifying complete domain models is too high.
Migration, mutation and drift are by far too rarely integrated in the models impeding the exploration of new strategies.
Copy number variations (CNV) are important causal genetic variations for human disease; however, the lack of a statistical model has impeded the systematic testing of CNVs associated with disease in large-scale cohort.
Moreover, the pathogenic changes of both liver architecture and vascularisation in cirrhotic livers, as well as the lack of "true-to-life" in vitro models have impeded the development of an effective anti-fibrogenic drug.
Two-thirds of breast cancers express estrogen receptor alpha (ERα) and are estrogen-dependent for growth, yet the unavailability of accurate in vivo models has long impeded the characterisation of critical events that lead to the development of these luminal subtypes of the disease.
Curcumin inhibits the proliferation of diverse tumor cells in culture, prevents carcinogen-induced cancers in mouse models, and impedes the tumor growth in various xenotransplant and orthotransplant mouse models [ 7, 8].
Researchers currently face many restrictions on the use of animal models, which impedes the development of effective therapies for PD.
More extensive analyses using knockout mouse models revealed that disruption of ABCG1 expression impeded the rate at which mice gained weight over a 12-week period.
