Sentence examples for model identified compound from inspiring English sources

In vivo assay in U937 xenograft model identified compound 7h as a potent, orally active HDACI.

The Health and Environmental Sciences Institute of the International Life Sciences Institute ILSI/HESI Cardiovascular Safety Subcommitteeee outlined a set of in vivo telemetry studies to determine how well this preclinical model identified compounds known to cause torsades de pointes (TdP) and prolong QT interval in humans.

ADMET studies coupled with a behavioral test using the amphetamine-induced hyperactivity model identified four compounds possessing drug-like profiles and having antipsychotic properties.

One OnPLS model was built from all genes, proteins and metabolites (i.e. all variables), and one model was built using only identified compounds (targeted variables).

As a case study, we perform a combinatorial screening in a huge composition space of around half a billion compounds, and find that our model successfully identifies compounds not in our training set.

Since PAO1 can also form biofilm on duckweed, it can also provide a model for identifying compounds that limit biofilm formation and provides a platform for observing biofilm-deficient mutants.

Here, we describe the development of a hypoxic model to identify compounds targeting mycobacterial respiratory functions and ATP homeostasis in whole mycobacteria.

We present here a new in vitro model for identifying compounds that target metastasis at its most vulnerable and rate-limiting step, which is the escape of micrometastatic cells from the suppressive effects of the normal extracellular matrix [ 11].

The accumulation of DMPK data of compounds in pharmaceutical companies has led to the development of in silico models to predict DMPK profiles of newly identified compounds.

Our pharmacophore model identified a number of potential lead compounds from which we selected 11 compounds to evaluate.

Some progress is being made in animal models to identify compounds that temporarily inhibit efflux pumps while momentarily allowing normally excluded therapeutic compounds to enter the brain[103], though the apparent draw back appears to be unforeseen dose related toxicity.