Sentence examples for model has been engineered from inspiring English sources

A second kind of model has been engineered by transfecting the ER negative breast cancer Hs578T cell line with a FLAG-tagged and inducible version of ERα, ERβ or ERβ cx, and was used for microarray analysis of gene expression [ 25].

In mice alone, multiple targeted transgenics, chimeras, a conditional knockout, and a regulable cell-type-specific disease-rescue model have been engineered.

A first series of cellular models has been engineered by transfecting the ERα positive MCF-7 cell line with a plasmid expressing an inducible FLAG-tagged version of ERβ.

A number of genetic mouse models have been engineered to express oncogenes in melanocytes [3].

To enable more systematic and better-controlled investigations, transgenic mouse models have been engineered that are characterized by mutated Mecp2 [13] [16]–[13] [16]

Finally, transgenic mouse models have been engineered to mimic celiac disease, most notably the NOD Ab° DQ8+ mouse, which expresses human DQ8 in an endogenous MHC class II-deficient (Ab°), autoimmune-prone (NOD) background [36].

As human approaches are limited, murine animal models have been engineered to study the diverse pathobiology of 22q11.2DS.

Attractive animal models have been engineered to investigate the in vivo functions of the β-catenin pathway in the mouse mammary gland.

The Western Reserve strain of vaccinia virus (VV) is the most virulent strain of VV in animal models and has been engineered for tumor selectivity through two targeted gene deletions (vvDD).

Most recently, a model for ICF syndrome has been engineered by generating Dnmt3b mutations in mice [18].

Recently, the Sleeping Beauty (SB) transposon system has been engineered to model cancer in mice.