Sentence examples for model harboring a from inspiring English sources
To directly assess the levels of different types of spontaneous mutations in organs and tissues during aging, we have used a mouse model harboring a chromosomally integrated cluster of lacZ-containing plasmids that can be recovered and analyzed in Escherichia coli.
We next took advantage of a previously published rat model harboring a disease-causing point mutation in the gene encoding MKS3 [18], which results in polycystic kidney disease [17] as well as hydrocephalus [9].
While the Apc-Cdkn1a network was generated using tumor-specific ApcMin/+ data – a model harboring a number of background genetic lesions [41] – the intestinal tissue obtained from the Apc1638N+/− and Cdkn1a−/− mice at 3 months of age is relatively polyp free, thus allowing us to gauge the effect of a single genetic perturbation on the pre-neoplastic epithelium.
Other studies have examined the expression of the C9orf72 gene using a transgenic mouse model harboring a targeted LacZ insertion [ 32].
Given the importance of 1p36 deletion CNVs in humans, we decided to study a chromosome-engineered mouse model harboring a 4.3 Mb deletion in 4E2 [ 19].
Moreover, young mouse model harboring a mutation favoring generation of Aβ 1-42 over Aβ 1-40 had a low Aβ 40/42 ratio, was shifted to plaque deposition [ 45].
The sod1 zebrafish ALS model harbors a fluorescent heat shock stress response (HSR) reporter gene (hsp70-DsRed).
Our mouse model harbors a truncation variant in A-band TTN, making it a good mouse model for a wide spectrum of human DCM.
This autochthonous model harbors a KrasG12D mutation and overexpresses Twist1 and Ddx3, which made it a suitable model to test efficacy of RK-33 (Fig 6B).
The myodystrophy Large myd mouse model harbors a mutation in the gene Large, which encodes a glycosyltransferase that presumably alters the glycosylation of α-DG.
To validate our findings in vivo, we initially used an orthotopic xenogeneic mouse model and, subsequently, an orthotopic syngeneic mouse model, since the latter model harbors a functional immune system.
