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Rats of model groups showed a significant decline in the mRNA levels of IDE (Fig. 4d, P < 0.01) and NEP (Fig. 4e, P < 0.01).
However, the levels of immunopositivity in the non-acup and model groups showed no significant differences (all P > 0.05; Figures 3B, 4A, B and C and 5A; Table 1).
However, the numbers of pMEK1/2-, pERK1/2-, and pp90RSK-positive cells in the U0126 + EA and model groups showed no significant differences (all P > 0.05; Figures 4B and C and 5A; Table 1).
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HDL in model group showed no significant difference from blank group at week 13.
However, HDL value in model group showed no significant difference from blank group at week 13.
Model group showed severe red swelling in foot and toes and local depilation.
The offspring of the model group showed weakened PPI and weakened latent inhibition.
Six-week OAB model group showed much more RV but less voiding efficiency when compared with 6-week sham group or 2 and 4-week OAB model group.
Compared to Control group, rats in Model group showed severe pathological changes, such as bronchiole stenosis, alveolar cavity expansion, alveolar destruction, inflammatory cells infiltration and mucosal hyperplasia.
In the 15th week, widespread malignant cells were observed in the four groups receiving DEN, whereas the model group showed most severely malignancy (Fig. 1).
At the appearance, the liver and spleen in the model group showed enlargement significantly, but the enlargement was less significant in the preventive and treatment groups.
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